What is the Endocannabinoid System?

What is the Endocannabinoid System?

CBD and Endocannabinoid System

The role of the Endocannabinoid System is very complex, as it regulates the biochemistry of most of the cells that exist in our body. Different research has shown that the Endocannabinoid System functions as an “SOS” mechanism that is activated when our bodies become unbalanced for some reason. For example, it is activated when we suffer a physical injury, when we encounter pathological microbes and also when we feel emotional pain or get stressed. It is like the first line of defense that occurs and activates all the other mechanisms necessary to restore the body’s stability as soon as possible.


Various researchers have stated that the Endocannabinoid System “may have therapeutic potential in almost every disease affecting humans, including obesity and metabolic syndrome, diabetes and its complications, neurodegenerative, inflammatory, cardiovascular, hepatic, gastrointestinal and skin diseases; pain, psychiatric disorders, cachexia, cancer, and chemotherapy-induced nausea and vomiting, among many other health problems.” The importance of this system to our survival and well-being cannot be overemphasized.

CB1 and CB2 Receptors in 2 distinct locations:

“It’s not the Cannabis plant that has many effects, it’s the Endocannabinoid System that determines them…”

The distribution of Cannabinoid Receptors in our organism is unique. CB1 Receptors are found mainly in the central nervous system, in areas related to cognitive functions, memory, anxiety, pain, sensory perception, visceral perception, motor coordination, and areas related to some endocrine functions. They are also found in some areas of the peripheral nervous system, testes, heart, small intestine, prostate, uterus, bone marrow and vascular endothelium.

CB2 receptors are predominantly found in immune system related structures, B and T lymphocytes, monocytes, macrophages, glial cells in CNS, in addition to the spleen. The distribution of CB receptors is completely different from that of other existing receptors in organisms, but it is very similar from one species to another, which allows us to think that their physiological function has been maintained during evolution.

Needless to say, this System is of immeasurable importance, and we are only beginning to understand the abundant complexities that take place.

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